Anti CyclicCitrullinated Peptide(CCP)

Test/Profile Name

Anti CyclicCitrullinated Peptide(CCP)

Test/Profile Code

T000622

Clinical Usefullness

Aid in the diagnosis of Rheumatoid Arthritis  (Ra)

Conjunction  With Other clinlcal information


Synonyms (Also knowns as)

Anti Citrullinated Antibody

Anti Citrulline

Anti-CCP (Cyclic Citrullinated Peptide)

Anti-Citrullinated Ab

Anti-Citrullinated Antibody

Anti-Citrulline Antibody

Anti-Cyclic Citrullinated Peptide (CCP)

CCP (Cyclic Citrullinated Peptide)

Citrullinated Ab

Citrullinated Antibody


Specimen Type and Minimal Volume

Serum 1 ml
Serum : Plain Tube (Red Top)

Forms

Not required

Test Equipment

Abbott Architect i 1000 SR

Test Method

Chemiluminescent microparticle immunoassy (CMIA)

Reference Range

Less than 5.0 U/ml       - Negative

More than 5.0 U/ml     - Positive


Include Test

N/A

Reporting Time (Turn Around Time; TAT)

8 hrs

Clinical Information

Anticyclic citrullinated peptide (anti-CCP) antibody levels are characteristically elevated in rheumatoid arthritis, although they can be elevated in other rheumatologic conditions associated with inflammatory arthritis, such as systemic lupus erythematosus.  Anticitrullinated protein antibody (ACPA) level was added to the 2010 American College of Rheumatology(ACR)/European League Against Rheumatism (EULAR) diagnostic criteria for rheumatoid arthritis. These criteria, including ACPA levels, identify more patients with rheumatoid arthritis than the previous 1987 criteria.  ACPA can be present in the early presentation of rheumatoid arthritis while the rheumatoid factor is negative. Therefore, if ACPA is identified, the patient likely has rheumatoid arthritis.

The antigen used in most assays is filaggrin, although other antigens are available.  ACCP antibodies are a subset of ACPA and are not completely cross-reactive with other citrullinated proteins. [ The most common test for anti-CCP2 has a sensitivity of 61.6-75.2% for rheumatoid arthritis and specificity of 94-99%.   Although multiple assays are available, including antimutated citrullinated vimentin antibody and several generations of anti-CCP, they have all been shown to have comparable diagnostic performance.


Related Disease/Condition

Rheumatoid Arthritis
Autoimmune Disorders

Related Test

Rheumatoid Factor
ESR
C-Reactive Protein
ANA
Synovial Fluid Analysis