Test/Profile NameAnti Thyroid Peroxidase (TPO)(Microsoml)
Aiding in the diagnosis of thyroid autoimmune disorders
Differentiating thyroid autoimmune disorders from nonautoimmune.
Goiter or hyperthyroidism as a diagnostic tool in deciding whether to treat a patient who has subclinical hypothyroidism.
Synonyms (Also knowns as)
Thyroid Peroxidase Antibody
TPO (Thyroid Oxidase)Antibodies
Thyroid Antibody Group
Thyroid Microsomal Antibodies
Specimen Type and Minimal VolumeSerum 1 ml
Serum : Plain Tube (Red Top)
Test EquipmentAbbott Architect i 2000 SR
Test MethodChemiluminescent microparticle immunoassy (CMIA)
0.5 -5.61 IU/ML
Reporting Time (Turn Around Time; TAT)8 hrs
In patients with subclinical hypothyroidism, the presence of thyroperoxidase (TPO) antibodies predicts a higher risk of developing overt hypothyroidism, 4.3% per year versus 2.1% per year in antibody-negative individuals. Furthermore, it raises the concern that such patients may be at increased risk of developing other autoimmune diseases, such as adrenal insufficiency and type 1 diabetes.
The frequency of detectable anti-TPO observed in nonimmune thyroid disease is similar to the 10% to 12% observed in a healthy population with normal thyroid function.
There is a good association between the presence of autoantibodies against TPO and histological thyroiditis. However, in view of the extensive regenerative capacity of the thyroid under the influence of thyroid-stimulating hormone, chronic thyroid disease may be present for years before the clinical manifestation of hypothyroidism becomes evident, if ever.
Related Disease/ConditionHashimoto thyroiditis
Related TestAnti thyroglobulin Antibody
Free T3 and Total T3